A 43-year-old hospital patient has been missing from The Alfred all night, with grave fears for his health.

Stephen Waller walked out of the ward just before 8:30pm and boarded the No 72 tram towards Camberwell.

He may be headed home to South Yarra but is in desperate need of medication.

Stephen is described as about 182cm tall, with short grey hair, balding and is gaunt.

He was last seen wearing a grey jacket and denim jeans with stains.

Anyone who sights Stephen is urged to contact Triple Zero (000) or who knows of his whereabouts is urged to contact Southbank police station on 8635 0900.

KIIS 1011 Melbourne